Garcinia cambogia, also known as garcinia gummi-gutta and brindleberry, is a small pumpkin-looking fruit native to Indonesia. It contains hydroxycitric acid (HCA), which is similar to citric acid in its structure.

HCA’s weight loss properties were discovered in mice by researchers 1990s. Garcinia cambogia had become popular as a dietary supplement, falling in and out of the public eye over the course of twenty years. Without enough research to substantiate the mechanism by which HCA and cambogia work, it became a novelty that not many were sure how to properly use.

What Garcinia Combogia Does

It turns out that HCA partially blocks citrate lyase, an enzyme that helps turn starches and sugars into fat. If that enzyme can be blocked, and with a few other preparations, carbohydrates are turned into energy instead of being stored as fat. If that sounds exciting, that’s because it is – but don’t pick up that garcinia bottle just yet. There’s a lot more to know about this peculiar little fruit.

How Garcinia Combogia Works

The Department of Pharmaceutical Science in South Africa explains: “HCA is a potent inhibitor of adenosine triphosphate-citrate lyase, a catalyst for the conversion process of citrate to acetyl-coenzyme A, which plays a key role in fatty acid, cholesterol and triglycerides syntheses.”

Simply, it is indicated that garcinia cambogia stops the synthesis of several enzymes responsible for the creation and storage of fat. And while not of particular interest in regard to weight loss, garcinia cambogia also shows “hypolipidemic, antidiabetic, anti-inflammatory, anticancer, anthelmintic, anticholinesterase and hepatoprotective activities.

In addition to its enzyme blocking capabilities, HCA seems to suppress the appetite in an uncommon way. Amphetamine-based and other stimulant drugs suppress the appetite by making the subject less hungry. The HCA in cambogia, by contrast, makes the satisfaction that comes with eating a meal feel more pronounced, making the subject less likely to take another bite. The mechanism by which this occurs is not known yet, but HCA’s interaction with serotonin may give some clues.

What’s the Catch?

Serotonin is one of several pleasure hormones the brain pumps out. But unlike dopamine, serotonin doesn’t operate like a reward system. Rather, it makes one feel happy and content when resource requirements are met – food, for instance. Serotonin is secreted in the gastrointestinal tract likely for this reason.

Some researchers believe HCA stimulates the secretion of the amino acid 5-hydroxytryptophan, a direct precursor to serotonin.

One possible side effect of HCA is serotonin syndrome: An overproduction of serotonin that leads to dizziness, confusion, stuttering, and other effects. This side effect comes about if cambogia is mixed with certain specific drugs: Dextromethorphan (found in some cold medications), Tramadol, Demerol, and SSRIs like Zoloft.

So long as those drugs are shied away from and the instructions further down are followed, there shouldn’t be much to worry about.

In fact, the raised serotonin levels brought by HCA have been shown to improve mood.

Garcinia Combogia Usage: Some Need-to-Know Info

Harry Preuss, a researcher and pathologist at Georgetown University, was interested enough in HCA’s attributes that he researched it during the lull in its popularity. He reportedly thought that past studies performed on HCA were “discouraging but not conclusive.”

“You have to take the right dose of the right product, and you have to take it properly,” Preuss, former president of the American College of Nutrition, said to Dr. Bowden in an interview for “In the JAMA (Journal of the American Medical Association) study, they used whatever the dose was at the time, and they never even mentioned the type of citrate they used. You have to give enough so that it reaches the sites in the body that it needs to reach.”

Preuss pressed the point that maximization of bioavailability is of the utmost importance with HCA. If one ignores this advice, a repeat of the JAMA’s results is bound to occur – that is, it will fail to work.

There are three different forms of hydroxycitrates. Each is blended with calcium, potassium, or magnesium salts. These salts are added to decrease the rate at which HCA degrades into a lactone (useless) version of itself. The ratio these salts are added in commercial supplements is 1-to-1 or higher for this reason. However, “If you have almost a pure calcium hydroxycitrate, it’s just not going to work,” Pruess said.

Instead, a compound of HCA that is bound to calcium and potassium dramatically increases the effectiveness of HCA and its availability, according to Preuss. And luckily for you, the capsules offered by Natrogix contain both potassium and calcium in the correct proportions!

The result of Preuss’ double-blind study resulted in the HCA group losing 10.5 pounds compared to the placebo group’s loss of only 3.5. In addition, the HCA group had a 14%-16% reduction in the amount of food eaten per meal. All participants were on a monitored diet that did not contain any high-fat or high-sugar foods (candy, bacon, etc.).

The Correct Way to Use Garcinia Cambogia 

Natrogix offers 700mg of 95% HCA garcinia cambogia in capsules – but it’s not just a matter of taking it and waiting for it to work. It must be taken correctly. And that correct way is as follows.

While on empty stomach, researchers found that the study participants’ dosage was best at 1.5 grams – or about two (2) Natrogix garcinia cambogia capsules – three times per day before meals. Therefore:

  1. Make sure the stomach is empty. The appetite-curbing benefits of the supplement, in the above studies, work best when it is metabolized before food enters the body.
  2. Take two (2) capsules, three times a day, 30-60 minutes before a meal.
  3. Do not adjust the dosage higher.

And that’s it! The most common side effect of garcinia cambogia is headache or upset stomach, though if the above instructions are followed, that shouldn’t be an issue. However, if these unpleasant effects persist, lower the dosage to (1) capsule, three (3) times a day but still while on an empty stomach. As a side note: HCA is not a stimulant. As such, its affects are observed upon success but cannot be “felt” as it works.

As with other supplements and weight loss methods, diet and exercise combined with garcinia cambogia go a long way toward meeting your weight loss goal!

You can purchase Natrogix’s Garcinia Cambogia formulation with potassium and calcium here. Make sure to leave a review! Thanks for choosing Natrogix.